A Brief Review on Solid lipid Nanoparticles

A Brief Review on Solid lipid Nanoparticles

Author Name : Manish Choudhary, Iti Chauhan, Satyam Tyagi

ABSTRACT

Solid lipid nanoparticles were developed in early 1990s as an alternative to other traditional colloidal carriers like liposomes, polymeric nanoparticles and emulsions as they have advantages like controlled drug release and targeted drug delivery with increased stability. Solid lipid nanoparticles (SLNs) have emerged as potential drug delivery systems for various applications that are produced from physiological, biodegradable, and biocompatible lipids. Solid lipid nanoparticles (SLNs) are gaining importance due to the numerous advantages they offer as a drug delivery system. SLN incorporates poorly soluble drugs, proteins, biologicals, etc. SLN are prepared by techniques like high-pressure homogenization, and sonication and employs a wide range of lipids and surfactants. Physicochemical characterization techniques include particle size analysis, zeta potential and determination of crystallinity/polymorphism. Furthermore, drug loading and drug entrapment efficiency are common parameters used to test the efficiency of SLN. Most importantly, the functional assay of SLN is essential to predict the activity and performance in vivo. The present review focuses on the utility of SLN in terms of their advantages, production methodology, characterization, and applications. If properly investigated, SLNs may open new vistas in the therapy of complex diseases.

Keywords: Solid lipid nanoparticle, transdermal drug, lipid, emulsifier