Improvement of Drug-Associated Acute Intersti...

Improvement of Drug-Associated Acute Interstitial Nephritis by Corticosteroids

Author Name : Swalay Fedally, Liu Xi, Bin Peng, Zou Qinpei, Wan Zi Ming, B R Kureemun, Du Xiao Gang

Method: A retrospective analysis of 98 patients with AIN mediated by drugs were admitted at the 1^st Affiliated Hospital of Chongqing Medical University, China. The patients are divided into 2 groups (treated group and control group)with 49 cases each. According to age, each group are divided into 3 age-groups (18-30, 30-60 and >60 years) denominated A, B and C respectively. After admission, the two groups patients were treated with diuretics, nutrition support therapy, correction of the hydro-electrolyticdisorder or maintaining the acid-basebalance and other symptomatic treatment. Besides these therapies, patients in treated groupreceived steroids therapy.The main presentation, and blood and urinary analysis on the first day of admission, the first, second, 12^th and 24^th week were collected.

Results: Improvement in Urea (BUN) and Creatinine (Cr) level as well as other signs and symptoms in the treated group was quicker than that in the control group. Out of the 49 patients in the treated group, only 2 developedCKD after 24 weeks, while 6 patients in the control group endedwith ESRF for the same period of time. The prognosis of old AKI patients (age >60 years old)in both treated and control group were poorer than that of young and mid-aged patients. However, steroid treatment still took effect in the old patients.

Conclusion: Most of the AIN patients treated without steroids may still recover to normal. However, steroids help renal function to recover quickly, and the treatment may benefit to maintain a good short-term and long-term prognosis for AIN patients.

Keyword: Acute Interstitial Nephritis, Corticosteroids, Chronic Kidney Disease(CKD),Corticosteroids,Haemodialysis (HD).