A Comprehensive Review on Recent Trends in Tr...

A Comprehensive Review on Recent Trends in Treatment of Cutaneous T-Cell Lymphoma

Author Name : Ms Archana Kumari, Mr Aditya Thakur, Ms Priya Sharma, Dr Bhartendu Sharma

ABSTRACT Cutaneous T-cell lymphoma (CTCL) is a rare and complex form of extranodal non-Hodgkin's lymphoma that primarily affects the skin, though it can spread to other organs. One of the key challenges in managing CTCL is its uncertain cause and the wide variation in how it presents clinically. This makes diagnosis difficult and often leads to delays in treatment, as its symptoms frequently resemble those of benign skin conditions. CTCL is a chronic condition that tends to relapse, and treatment is primarily focused on managing symptoms and improving the patient’s quality of life rather than curing the disease. In its early stages, CTCL tends to progress slowly and is often mistaken for other less serious dermatologic conditions, such as eczema or psoriasis. Mycosis fungoides typically starts with patches or plaques on the skin, while Sezary syndrome is more systemic and involves the skin, lymph nodes, and blood. In addition to these clinical manifestations, histopathological analysis is essential for an accurate diagnosis, as the skin lesions of CTCL can mimic other dermatologic conditions. This article provides an in-depth review of both subtypes, including their clinical presentations, the role of histopathology in diagnosis, and the challenges that arise in distinguishing CTCL from other conditions. The importance of early detection and specialist involvement is emphasized throughout, as timely intervention can significantly improve outcomes for patients with this challenging disease.