A New RP HPLC Method Development, Validation ...

A New RP HPLC Method Development, Validation and Stability Indicating for the Estimation of FINERENONE in Bulk and Pharmaceutical Dosage Forms

Author Name : Lavanya Jilla, Raja Reddy Aleti, Ratna Sri Erusalagandi

ABSTRACT

A simple and selective LC method is described for the determination of Fineranone dosage forms. Chromatographic separation was achieved on a c₈ column using mobile phase consisting of a mixture of 10mM Phosphate Buffer pH 3.0: Methanol (80:20) with detection of 227 nm. Linearity was observed in the range 50-150 µg /ml for Fineranone (r² =0.9995) for drugs estimated by the proposed methods was in good agreement with the label claim. Fineranone was found to be simple, precise, accurate and high resolution and shorter retention time makes this method more acceptable and cost effective and it can be effectively applied for routine analysis in research institutions, quality control department in industries, approved testing laboratories, bio-pharmaceutical and bio-equivalence studies

Key words: Finerenone, chromatographic separation, high resolution, shorter retention, bioequivalence