A Review Compression and Compaction

A Review Compression and Compaction

Author Name : Abhufet R. Divekar, Dr. V. M Satpute, Prof S. R. Ghodke, Dr. H. V. Kamble

ABSTRACT The Various advantages such as high-precision dosing, manufacturing efficiency and patient compliance helped in manufacturing of tablets, the most popular dosage forms among all available dosage forms. Compaction, which is an essential manufacturing step in the manufacture of tablets, mainly includes compression (i.e., reduction of volume of the powder under consideration and particle rearrangement) and consolidation (i.e., formation of interparticulate bond to facilitate stable compaction). The success of the compaction process depends not only on the physico-technical properties ofdrugs and excipients, but also on the instrument settings with respect to rate and magnitude of force transfer. Instrumented punches/dies, compaction simulators and instrumented tablet punching machines can all be used to study the mechanical elements of tablet production Thesecould be used, among other things, in pharmaceutical research and development to look into fundamental compaction mechanisms, various process variables, scale-up parameters, troubleshoot problems, create a compaction data library, and fingerprint new active pharmaceutical ingredients (APIs) or excipients. The work of compaction, elasticity/plasticity, and time-dependent deformation behaviour of the under-discussed pharmaceutical powder are characterized using mathematical models, force-time, force-distance, and die-wall force parameters of tablet manufacture. Hence the current study topic is undertaken for detailed insights of compression and compaction (Powder properties, physics of compression, compaction eqautions, force involvedin compression, compaction profile, factors affecting, crushing strength, friability, lamination and camping)