A Review of Synthesis and Biological Activiti...

A Review of Synthesis and Biological Activities of Schiff Base and Their Derivatives

Author Name : Jismy Francis, Meena Chandran, Silvipriya K S, Ashly George, Dolphy Anto, K Krishna Kumar

ABSTRACT

The schiff base ligands are known as "Privileged Ligands" because they can be made quickly by condensing an aldehyde or ketone with a primary amine. A schiff base is an aldehyde or ketone's nitrogen analogue. Compounds from the schiff base family have important medicinal uses and are essential in the fight against microbes. Only aldehydes and ketones that do not readily aldolize in acidic media can be condensed with amines when a strong acid catalyst is present (such as BF₃-etherate, anhydrous ZnCl₂, or POCl₃). Stable azomethines are produced by aliphatic or aromatic ketone and aromatic aldehydes. Numerous natural, naturally derived and synthetic compounds contain imine or azomethine groups. It has been established that the imine group in these compounds is essential for their biological activities. In the creation of numerous lead molecules that are crucial for medicine, schiff bases are used. The presence of an electron lone pair in the nitrogen atom is related to the high pharmaceutical value of the azomethine group. Numerous scientists have produced and reported a wide range of biologically active compounds due to the synthetic versatility and relative simplicity of schiff bases. schiff bases are biologically active substances with a number of significant pharmacological properties, including anti-bacterial, anti-fungal, anti-inflammatory, anti-tubercular, anti-oxidant and anti-cancer activities. A lot of research has been done on the biological activity of schiff base metal complexes. The synthesis of schiff base complexes and their various biological functions are summarized in this review.

Keywords: Azomethine, Pharmacological properties, Privileged ligand, Schiff base.