A Review on Formulation, Development and Eval...

A Review on Formulation, Development and Evaluation of Orodispersible Tablets Containing Caffeine

Author Name : Ishant Diwakar Dahake

INTRODUCTION Orodispersible Tablets: Fast dissolving tablets are continuously gaining great success in the pharmaceutical market. The most popular solid dosage forms are tablets and capsules but the major drawback of these dosage forms for some patients is the difficulty to swallow it. Fast Dissolving Tablets are not only preferable for people who have swallowing difficulties, but also are ideal for active people. Such a tablet disintegrates instantaneously when placed on tongue, releases the drug that dissolves or disperses in the saliva. As the oral mucosa is highly vascularised, drugs that are absorbed through the oral mucosa can directly enter into the systemic circulation, bypassing the gastrointestinal tract (GIT) and therefore first‐pass metabolism in the liver. This result to a rapid onset of action, and greater bioavailability of the drug than conventional forms. These are ease of administration to the patient who cannot swallow, such as the paediatric, geriatric & psychiatric patients, elderly, stroke victims, bedridden patients, patient affected by renal failures. There is no need of water to swallow the dosage form, which is highly convenient feature for patients who are travelling. It also undergoes rapid dissolution and absorption of the drug produces quick onset of action. These also provide good mouth feel property that helps to change the perception of medication as bitter pill particularly in paediatric patient.