An Overview on Sustained Release Dosage Forms

An Overview on Sustained Release Dosage Forms

Author Name : Dhanashree Sonawane, Dr. Sarita Pawar

ABSTRACT

As the cost and complexity of developing novel pharmacological entities has increased, and as the therapeutic benefits of controlled drug administration have been recognised, more emphasis has been paid to the development of sustained or controlled release drug delivery systems (DDS).  As a result, we'll shift our attention to inventing sustained drug delivery that reduces dosing frequency or improves medication efficacy by localising the drug at the site of action, lowering the amount required, or ensuring uniform drug administration. The physicochemical features of the drug, the kind of delivery system, the disease being treated, and the patient's state, as well as the duration of therapy, the presence of food, gastrointestinal motility, and other considerations, all influence the design of oral sustained release DDS additional medicines being used at the same time The core ideas of a sustained drug delivery system optimise the many aspects of a medication, such as biopharmaceutical, pharmacokinetic, and pharmacodynamic properties, in such a way that therapeutic efficacy is increased, side effects are decreased, and disease cure is readily attained.. Maintaining a therapeutic index for medication molecules in blood plasma is crucial for effective treatment. Oral sustained release dose formulations were born out of these concerns, as well as others including recurrent dosing and variable absorption. The major goal of this review is to provide a comprehensive understanding of sustained release dose and its benefits, as well as to define the many factors for selecting a medicine for a drug delivery system.

Key-words:  Sustained release, Biological half-life, Drug properties