Analysis of Formulation Parameters Pertaining...

Analysis of Formulation Parameters Pertaining to Drug Release, Buoyancy of Gastro Retentive Drug Delivery Systems

Author Name : Shantveer Salger, Dr. G.V Suresh Kumar

ABSTRACT Over the past few decades, drug administration has matured, with a variety of intriguing tools and methods used to achieve a regulated drug input into the blood pool. Once-daily formulations of enteric coated oral dosage forms were created especially for this use. These once-daily or twice-daily preparations often use the gastrointestinal tract (GIT) to deliver the medication. Numerous dose forms have been developed that release, dissolve, or disintegrate the medication in the stomach before being absorbed from the small intestine. The efficacy of the regulated release of drugs in the stomach, which are then absorbed from the small intestine, is significantly hampered by gastrointestinal motility, a robust and fluctuating phenomena. Many medications can be taken orally for 24 hours using current release technology, but the medicine must be adequately absorbed throughout the entire gastrointestinal tract. The limited window for drug absorption in the GIT, stability issues, or low drug solubility in the GIT fluids are some major potential roadblocks. The gastrointestinal tract has a variety of pH zones, with the stomach being the most acidic, the intestines being less acidic to mildly alkaline, and the colon being alkaline. The power of gastric movements during the digestive and inter-digestive phases is determined by the dosage form's residency in the stomach, which is typically up to two hours. Food has no effect on the small intestine transit, which remains steady for three hours. The time of gastric emptying, not the small intestine transit time, determines when the dose form reaches the colon.