Anti T. B Drugs

Anti T. B Drugs

Author Name : Ms. Pranita Ajinath Pungle,Ms. Priti Lokhare

ABSTRACT In 1882, Robert Koch discovered the cause of tuberculosis, which was the first step toward discovering a cure. The sanatorium movement, which began shortly afterward in Europe and quickly extended to the United States, drew attention to the distress of those affected and sparked public health action. The antituberculosis benefit of streptomycin was announced in 1945, although application was limited by the rapid development of resistance. para-Aminosalicylic acid, also discovered in 1945, when combined with streptomycin was found to greatly reduce the occurrence of drug resistance. In 1952, isoniazid opened the modern era of treatment; it was inexpensive, well tolerated, and safe. In the early 1960s, ethambutol was shown to be effective and better tolerated than paraaminosalicylic acid, which it replaced. According to the World Health Organization, or WHO, which declared tuberculosis an international health crisis in 1993, the disease will infect an estimated 1 billion people by 2020, killing 70 million. Despite this issue, there has been little progress in the development of novel TB treatments. For example, over 35 years have passed since the introduction of a new class of chemicals for the treatment of tuberculosis. Thus, there is an urgent need for novel medications to combat this condition. Given this, this study focuses on prospective medication candidates in development for tuberculosis (TB)..