Antibiotic Resistant Pathogens and Their Mech...

Antibiotic Resistant Pathogens and Their Mechanism of Resistance

Author Name : Shah Khalid Ahmad, Balwinder Kaur, Sofi Basit Zahoor, Sheezma Nazir

ABSTRACT

Antimicrobial resistance (AMR) has emerged as a significant global threat to public health, rendering once-effective medications ineffective against infectious diseases caused by bacteria, viruses, fungi, and parasites. The consequences of AMR include serious illnesses, prolonged hospital admissions, increased healthcare costs, and treatment failures. In this study, samples from 60 patients of different age groups were analyzed to investigate the prevalence of antibiotic resistance and sensitivity. Various laboratory methods, such as the disk diffusion test (Kirby-Bauer method), broth dilution method, E-test, agar dilution method, and Minimum Inhibitory Concentration (MIC) test, were employed to assess the resistance levels in different bacterial strains. The results revealed a significant proportion of samples showing resistance to commonly used antibiotics, indicating the widespread nature of the problem. The most common resistant strains were observed against antibiotics like CZ, RP, and CIP. On the other hand, some antibiotics, such as LE and AK, demonstrated sensitivity among the patient samples. These findings highlight the urgent need for a global action plan to address the growing threat of AMR and the development of effective strategies to preserve the efficacy of existing antimicrobial agents. By understanding the prevalence of antibiotic resistance, healthcare professionals can make informed decisions regarding infection therapy and mitigate the impact of AMR on patient outcomes and healthcare costs.

Keywords: Antibiotic resistance, Health care, Antibiotic sensitivity, Patient outcomes