Assessment of Anti -Cancer Activity by using ...

Assessment of Anti -Cancer Activity by using Standard Procedures

Author Name : Dr. G. Usha Kiran, A. Supriya, A. Mounika, B. Akhila, N. Ahalya, T. Maneesha

ABSTRACT The study of anti-cancer activity looks into several substances and processes that stop the growth of cancer cells. By focusing on particular processes like angiogenesis and apoptosis, these compounds show promise in the development of efficient cancer therapies. To advance treatment approaches in the battle against cancer, it is essential to comprehend these interactions at the molecular level. When cells divide uncontrolled and infiltrate neighboring tissues, cancer is the result. Mutations in DNA are the cause of cancer. Most DNA alterations that cause cancer are found in regions of DNA known as genes. Genetic modifications is another term for these alterations. The first stage is called initiation, during which a mutation in a cell's DNA causes oncogenes genes that stimulate cell growth to become active, or tumor suppressor genes that limit cell growth to become inactive. Antimetabolites, hormones, natural products, and alkylating compounds are typically regarded as anti-cancer medications. More drugs potential exists for dacarbazine than for doxorubicin and etoposide. Although doxorubicin is more effective than etoposide, it still has anti-cancer properties. Doxorubicin and dacarbazine typically exhibit longer-lasting anti-cancer effect than etoposide, which may necessitate more frequent dosages. In the mouse skin papilloma technique produced by DMBA, dacarbazine exhibits more anti-cancer effectiveness than doxorubicin and etoposide. Dacarbazine exhibits stronger anti-cancer action than doxorubicin in the DMBA-induced Rat Mammary Gland Carcinogenic Method. Doxorubicin exhibits the longest duration of effect when compared to Etoposide and Dacarbazine