Characterization and Antimicrobial Assay of ...

Characterization and Antimicrobial Assay of Hydrochlorothiazide Schiff Base and its Metal Ion Complex

Author Name : Khushi Setpalani, Deepak Pandit, Shraddha Vikraman Pillai, Suparna Ghosh

DOI: https://doi.org/10.56025/IJARESM.2023.1201242045

ABSTRACT The synthesis and characterization of the Schiff base and Co (II) complex of the diuretic drugHydrochlorothiazide (HCT) are reported here. Schiff Base of the diuretic drug Hydrochlorothiazide(HCT) was synthesized with the help of Salicylaldehyde, supposed to increase the efficiency of the parentdrug. Subsequently, the Co (II) complexes of the HCT Schiff base were synthesized. The characterizationwas done by elemental analysis, molar conductance andIR spectrometry. The data confirms that the complex is non-electrolytic in nature and shows that it has a composition of ML2 type withoctahedral geometry. All adducts are non-hygroscopic in nature and stable at room temperature. Both the adducts, Schiff base of Hydrochlorothiazide and its Co(II) complex, are insoluble in water butfairly soluble in DMSO. The Schiff base of Hydrochlorothiazide and its Co (II) complex were tested for antimicrobial activity alongside the parent drug HCT, against Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus using the agar disc-diffusion method. The results of antimicrobial assay depicted that the adducts, Schiff base of HCT and its Co(II) complex show relatively good activity as compared to the parent drug, HCT.