Clinical Values of Enzyme Changes in Pancreat...

Clinical Values of Enzyme Changes in Pancreatic Cancer – Pre and Post Chemotherapy

Author Name : N. Sivakumar, B. Prabasheela, R .Arivazhagan, R. Vijayalakshmi

ABSTRACT

The extensive desmoplastic microenvironment, which is essential for tumor growth, invasion, metastasis, angiogenesis, immunosuppression, and chemoresistance, is thought to be the cause of PDAC's high aggressiveness. Since tumor cells' energy metabolism differs from that of normal cells and is mostly based on aerobic glycolysis, fatty acid oxidation, and glutaminolysis, it is regarded as one of the distinguishing characteristics of cancer. As a result, a deeper comprehension of the intricate molecular traits of pancreatic cancer is required. There is mounting evidence that alterations in serum enzyme levels are crucial for the initiation and spread of cancer. Before and after chemotherapy, cancer patients have a variety of biochemical serum enzyme indicators, including lactate dehydrogenase (LDH), adenosine deaminase (ADA), gamma-glutamyl transferase (GGT), amylase, and lipase imbalance. The meticulous monitoring of variations in serum enzyme marker levels greatly influenced the prognosis of the disease.