Duloxetine Induced Syndrome of Inapropriate ...

Duloxetine Induced Syndrome of Inapropriate Antidiuretic Hormone Secretion: A Case Report

Author Name : Suhiara Banu, Sana Fathima, Chintha Chandran, Shaiju S Dharan

ABSTRACT Syndrome Of Inappropriate Antidiuretic Hormone Secretion (Siadh) Is A Disorder Characterized By Excessive Release Of Antidiuretic Hormone (Adh), Leading To Water Retention, Dilutional Hyponatremia, And Impaired Urine Dilution. Several Medications Have Been Implicated In The Development Of Siadh, Including Antidepressants Such As Selective Serotonin Reuptake Inhibitors (Ssris) And Serotonin-Norepinephrine Reuptake Inhibitors (Snris). Duloxetine, a Widely Used Snri for Depression, Anxiety, and Neuropathic Pain. This Report Discusses A Case Of Duloxetine-Induced Siadh, Highlighting Its Clinical Presentation, Pathophysiology, And Management. Patients Typically Present With Symptoms Of Hyponatremia, Such As Confusion, Lethargy, Seizures, And, In Severe Cases, Coma. The Proposed Mechanism Involves Serotonin-Mediated Stimulation Of Adh Release, Leading To Inappropriate Water Retention. A 75 Year Old Female Patient Was Admitted With Complaints Of Tiredness, Decreased Response, And Difficulty In Walking. She Had A Past Medical History Of Type Ii Diabetes Mellitus, Dyslipidemia, Systemic Hypertension And Left Hemifacial Spasm For 20 Years. She Had A Medication History Of Duloxetine 20mg, Gabapentin, Prednisolone, Esomeprazole, Cilnidipine, Atorvastatin, Etoricoxib, Metformin And Chlorthalidone. The Own Medication Duloxetine Which Was Taken For Six Months That Resulted In Syndrome Of Inappropriate Antidiuretic Hormone Secretion. Therefore, The Particular Drug Was Stopped And Alternatives Were Started