Evaluation of Utility of Urinary Phenylethyla...

Evaluation of Utility of Urinary Phenylethylamine as a Marker of Attention Deficit Hyperactivity Disorder in Children: A Case Control Observational Study

Author Name : Remya Joy, Dr. Suresh Babu, Dr. Sharmila K P, Dr. Vishakh R

ABSTRACT According to the worldwide prevalence of attention-deficit/hyperactivity disorder (ADHD) is estimated to be approximately 5%.Finding an accurate biomarker test for ADHD would have undeniable advantages, but we also need to consider the potential downsides that may arise as a consequence of this discovery.The main objective of the study is to examine the Evaluation of urinary Phenyl ethylamine in children with and without the Attention Deficit Hyperactivity Disorder population.In order to do this, the study mainly focused on quantitative aspect so that in this study 20 urine samples were collected (10 controls and 10 cases).To clarify the mechanism of neurochemical metabolism in attention deficit hyperactivity disorder (ADHD), we measured the urine levels of PEA using high performance liquid chromatography (HPLC). Case patients and healthy controls are often used to assess the diagnostic sensitivity and specificity of a biomarker.Since the present "gold standard" relies on informants' and physicians' perceptions, arriving at correct diagnosis is a laborious and time-consuming process. Considerable effort has been put towards discovering diagnostic biomarkers for mental disorders such attention deficit hyperactivity disorder (ADHD).Various clinical studies using different clinical evaluation by rating scale to clarify conclusive diagnosis of ADHD. Here is a method to evaluate urinary PEA in children with ADHD. We confirmed that the levels of urinary PEA in children with ADHD were significantly lower than those in controls.