Exploring the Potential Benefits and Risks of...

Exploring the Potential Benefits and Risks of 2, 4-Thiazolidinediones (Tzds) in the Management of Diabetes and Related Conditions

Author Name : Deepika Kumari, Ritu Kainth, Sukhdeep Singh, Pushkar Mehta, Amisha Gautam, Parwinder Singh, Paramjot Saini, Asmat Azmi, Pallvi Kumari, Vishakha Patial

DOI: https://doi.org/10.56025/IJARESM.2023.115232073

ABSTRACT TZDs have been demonstrated to enhance insulin sensitivity and glucose absorption in muscle and adipose tissues, resulting in better glycemic control in type 2 diabetes patients. TZDs have also been demonstrated to have potential benefits in terms of lowering the risk of cardiovascular disease and improving lipid profiles. The potential benefits and hazards of a class of medications known as 2,4-thiazolidinediones (TZDs) in the treatment of diabetes and related disorders are discussed in this article. According to recent research, cardiovascular toxicity with rosiglitazone and a rise in bladder cancer with pioglitazone is no longer serious concerns. TZD use is also connected with major hazards, such as an increased risk of bone fractures, edema, and weight gain. Furthermore, TZDs have been linked to an increased risk of bladder cancer, and long-term use may result in liver damage. Overall, TZDs can be an effective tool in the treatment of diabetes and related disorders, but doctors must carefully balance the potential advantages with the hazards associated with their usage. Patients should be constantly monitored for side effects, and alternate treatment options should be sought when necessary. Keywords: Type 2 diabetes, Pharmacological Effects, Clinical Management, Risk Factors, Pioglitazone, Rosiglitazone, Heart failure, metabolic disorder, Bone fracture