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Formulation and Evaluation of Controlled Release Tablet of Ketorolac Using Natural Polymers
Author Name : Karishma W. Kuthe, Rahul H. Kasliwal, Yogesh N. Gholse, Kajal L. Bisane
Controlled releases tablets are used for prolong duration of action with minimal therapeutic effect and formulated with natural high intense polymer to achieve controlled release of API with loading dose and maintenance dose. The aim of the research was to formulate and evaluate controlled release tablet by using natural polymers. The Direct compression method was used for the preparation of controlled release tablet. In this study, there was 7 formulations were prepared (F1 to F7), among all formulations F3 formulations shows better performance, it consists of ketorolac, and combination of polymer (almond gum and guar gum) having ratio (1:1). The all parameters of F3 formulation was angle of repose (23.530), tapped density (0.477g/ml), bulk density (0.402g/ml), compressibility (11.19%), Hausner’s ratio (1.101), weight variation 299±0.99mg, drug content (98.68±0.13%), hardness (4.48±0.31), thickness (3.52±0.05mm), friability (0.29±0.25rpm), drug release (88.06±1.49%). DSC and FTIR result shows no interaction between drug and recipients. The drug content studies showed uniform and homogeneous distribution of drug into the tablet and also show good drug release for 8 hrs. Hence, it indicates similar quantity of polymers required to prepare controlled release tablet of ketorolac. The release data of the controlled release tablet best fit korsmeyer-peppas model with (n=0.693) value. It conclude that controlled release tablet of ketorolac is formulated and evaluated and prepare for marketed use.
Key Words: Controlled Release Tablet, Ketorolac, Natural Polymers, Almond Gum, Guar Gum.