Formulation And Evaluation of Gastro Retentiv...

Formulation And Evaluation of Gastro Retentive Floating Tablet of Losartan Potassium Using Naturally Occurring Wax

Author Name : Mr. Sheikh Mohiuddin Shaikh Rafiuddin, Ms. Karishma A. Nikose, Ms. Minal K.Gharpure, Mrs. Farheen Asif Budhwani, Ms. Radha S.Prayag, Ms. Rasika P.Joshi, Ms. Parvin I. Shaha

ABSTRACT

In the present study, Gastro Retentive Floating Drug Delivery systems (GRDDS) of Losartan potassium, an antihypertensive drug, with an oral bioavailability of only 33% (because of its poor absorption from lower gastrointestinal tract) have been designed to increase the therapeutic efficacy & gastric residence time and to reduce frequency of administration. Losartan potassium having a short biological half-life of 1.5 -2 h is eliminated quickly from the body leading to low therapeutic efficacy. Therefore a sustained release medication was advantageous so as to achieve the prolonged therapeutic effect and to reduce peak and valley effect in plasma concentration. This can be achieved by formulating modified gastro retentive sustained release dosage forms which resides in the stomach for sufficient time to release the drug in vicinity of the absorption zone. The tablets were prepared by melt granulation (fusion method), by employing polymer such as HPMC K15 M and Sunflower wax and in various concentrations. sodium bicarbonate used as gas generating agent to reduce floating lag time. The prepared granules were evaluated for angle of repose, bulk density; tapped density, compressibility index and Hausner’s ratio and results obtained were in compliance with the pharmacopoeial standards. Compressed formulations were further evaluated for thickness, friability, hardness, floating lag time swelling index and in-vitro dissolution studies. All the formulations showed good results which were in compliance with pharmacopoeial standards.

Keywords: Floating tablet, Losartan potassium, Sunflower wax.