Formulation and Evaluation of Herbal Eco-Frie...

Formulation and Evaluation of Herbal Eco-Friendly Medicated Chewing Gum

Author Name : Amrata S. Mantri, Ram S. Sakhare, Anant N. Deshpande, Omprakash G. Bhusnure , Priyanka B. Parekar , Ashwini V. Todkari

ABSTRACT An attempt is made to formulate biodegradable medicated chewing gum to prevent Oral Submucous Fibrosis (OSF) which is the major health issue affecting 2.5 million Indian population under the age of 40 years, using natural gum base. To avoid the discard issue of gum cud, natural gum base of Triticum aestivum (wheat grain) was explored because of its biocompatible nature and easy availability. Prolamin, extracted from wheat, showed good chewing capacity, elasticity, high water retention capacity, antifungal activity, and compatibility with the drug.Amount of calcium carbonate (texturizer) and gum base were selected as independent variables. Elasticity and drug release were considered as the dependent variables. All batches were evaluated for the content uniformity, weight uniformity, stickiness, physical appearance, in-vitro drug release study etc. Aloe vera and curcumin play a vital role in the management of OSF.