Formulation and Evaluation of Lamotrigine Nan...

Formulation and Evaluation of Lamotrigine Nanosuspension

Author Name : Divya Shah, Jhanvi Chunara, Nandit Shah, Karishma Patel, Dr. Chainesh shah, Dr. Umesh Upadhyay

ABSTRACT

The solubility of a medicine can be a limiting issue in its formulation into a suitable dosage form, and it has a significant impact on its effectiveness. Nano suspensions are colloidal dispersions of pure medication particles stabilised by surfactants that are submicron in size.  Because of their versatility and specific characteristics, nano suspensions have emerged as a viable technique for the efficient delivery of hydrophobic medicines. The emulsification solvent diffusion approach was used to prepare lamotrigine nano suspension with the goal of overcoming the limiting factor.

Nano suspension has the potential to address several formulation and drug delivery challenges often associated with poorly water and lipid soluble medicines due to its submicron particle size and unusual physicochemical features. When taken orally, lamotrigine undergoes substantial hepatic metabolism, and its absorption is hampered by the presence of food. The goal of this work was to create a Nano suspension of lamotrigine and explore its formulation properties. Nano suspensions are now being studied for use in a variety of medication delivery methods, including oral, ophthalmic, brain, topical, buccal, nasal, and transdermal routes.

Keywords: Lamotrigine, Nano suspension, Quality by Design (QBD), Epilepsy, Critical Quality Attributes (CQA), Technology Advancement.