“Formulation and Evaluation of Luliconazole...

“Formulation and Evaluation of Luliconazole Soap Strips for Dermal Infections”

Author Name : Miss Ankita. C. Deshmukh, Mr. Mukesh. T. Mohite, Mr. Vaibhav vaidya

ABSTRACT

Antifungal paper soap strips of luliconazole were prepared & evaluated for dermal infection because the presence of thick foam on the infected part causes hydration of stratum corneum for better penetration of drug. The formulation and evaluation of medicated soap strips were carried out in two phases. Phase-1 studies optimization, which was carried out to study water absorption capacity using different types of papers like Whatman filter paper no. 1,40, 41, 42, filter paper , bond paper, butter paper by determining the parameters weight gain,size, shape, foam test. From these parameters best soap, concentration of liquid soap solution & papers were selected. Phase-2 studies involve incorporation of drug in best soap solution and papers chosen from phase-1 studies. The medicated soap strips were dipping the selected paper in drug containing soap solution.The prepared medicated paper soap strips were characterized for weight gain, Foam test , Drug content uniformity, FTIR, In vitro drug release studies using diffusion cell with hydride cellophane membrane.

Key Words: Dermal Infections, Luliconazole, Thick Foam, Hydration Of Stratum Corneum, Medicated Paper Soap Strips, Whatman paper