Formulation and Evaluation of Multiple Emulsi...

Formulation and Evaluation of Multiple Emulsion of Vancomycin HCl

Author Name : R. P. Sonwane, S. R. Gawande

ABSTRACT

Multiple emulsions have been proposed to have numerous uses including their use for enhancement of bioavailability or as a prolonged drug delivery system. But the inherent instability of this system needs to be overcome before they find potential application in pharmaceuticals. Multiple emulsions are often stabilized using a combination of hydrophilic and hydrophobic surfactants. The ratio of these surfactants is important in achieving stable multiple emulsions. Vancomycin was selected as a model drug to study the potential of multiple emulsion to improve bioavailability with the hypothesis that improvement of drug release profile will reflect the enhancement of bioavailability of the drug.

The objective of this study was to prepare multiple emulsion of Vancomycin by two step emulsification using different nonionic surfactants, Tweens & Spans, and evaluate for stability, in vitro drug release. The study concluded that stable multiple emulsion with high entrapment efficiency can be prepared by two step emulsification method using Spans40, Span60, Sapn80 as primary emulsifier and Tween20, Tween40, Tween60, Tween80 as secondary emulsifier.

Keywords: Multiple emulsions, Non-ionic surfactants, Vancomycin, Bioavailability, Stability.