Formulation and Evaluation of Selegiline Fas...

Formulation and Evaluation of Selegiline Fast Dissolving Tablets

Author Name : Dr. Vijaya Sindhuri Gopu, Mohammed Abdul Amer, Mohammad Tayyab, Mir Ahsan Ali, Mohammed Ajaz

ABSTRACT The objective of the study was to formulate and evaluate Fast Dissolving Tablets of Selegiline Direct compression method was used to formulate orally disintegrating tablet of Selegiline by employing different super disintegrates, polymers, and magnesium stearate (lubricant), Talc. These prepared formulations were then evaluated. Dissolution and drug content tests were performed using USP apparatus II and ultraviolet spectrophotometry, respectively. All formulations showed compliance with pharmacopeia standards. The effect of super disintegrates concentration and direct compression method on drug release profile was studied. Release profile of F4 were found to be satisfactory comparing to other formulations. F4 Formulation as processed excipient was found to be the best super disintegrates for the preparation of Selegiline fast dissolving tablets formulations. Due to it has exhibited faster disintegration time and best dissolution profile when compared to other formulations.