Formulation and Evaluation of Tablets Using M...

Formulation and Evaluation of Tablets Using Multiple-Unit Pellet System Technology: The Latest Review

Author Name : G.S. Sri Lekha, Dr. M. Sunitha Reddy

ABSTRACT

The oral route of drug administration is the most common and user-friendly method of drug delivery. Multiple Unit Pellet Systems (MUPS) tablets have become popular in the design of solid dosage forms in recent years. When compared to monolithic dose forms, MUPS is thought to have pharmacokinetic advantages. MUPS technology is used to compress a mixture of drug-containing pellets and powder excipients into a multi-particulate pharmaceutical solid dosage form. Because it exhibits increased bioavailability and improved pharmacological properties, the pharmaceutical industry has adopted MUPS technology as an alternative to conventional, immediate (or) modified-release tablets, including delayed-release, enteric-coated pellets containing various drugs, and tablet form can be used to protect the API from gastric media. Pelletization is the process of agglomerating tiny powdered medications or excipients with a binder solution to form small free-flowing, spherical, or semi-spherical particles. MUPS compositions offer a lower risk of local irritation and toxicity, reduced dose dumping, minimum plasma concentration variations, and the possibility of administering high-strength pharmaceuticals when compared to alternative drug delivery methods.This review aims to facilitate the future development of manufacturable MUPS tablets with drug release characteristics similar to those of the originally coated pellets.

Keywords: MUPS, Pellets, Delayed-release, Enteric-coated pellets, Pelletization, Dose dumping.