Formulation Development and Evaluation of Oph...

Formulation Development and Evaluation of Ophthalmic In-Situ Gel of Moxifloxacin Hyadrochloride

Author Name : Ajit Tuwar, Sheetal Gondkar, R. Bachhav

ABSTRACT An in-situ ophthalmic gel would be made using a variety of different natural mucoadhesive polymers. Analytical technique validation for in-situ gel formulation intended for ocular use. The identification and purity of moxifloxacin hydrochloride have been confirmed by the preformulation and evaluation investigations. The medication is compatible with all of the polymers that are used, according to research that used infrared spectroscopy of roxifloxacin hydrochloride both alone and in physical mixes with Carbopol 974 and HPMC K15M. It was decided that the provided formulations' clarity was adequate. The ophthalmic pH range (5.05-6.2) was determined to be the permissible range for all formulations' interactions with ocular tissues. The viscosities of each formulation were significantly influenced by the concentrations of HPMC K15M and Carbopol 974. The gel strength and bioadhesive strength of the formulations are comparable to the viscosity values. All of the formulations had drug contents between 97.8 and 99.7%, which was within permissible limits. The formulation including 0.4% by weight of carbopol 974 and 0.2 by weight of HPMC K15M showed the greatest release, or 4.29%, after 8 hours, indicating that the formulation had a protracted release, according to the results of the release kinetics analysis. This enhanced formula was also supported by Design Expert 7.0.0's optimisation programme. It has been shown that tonicity is maintained by the improved formulation. The improved formulation passed a sterility test. There was no ocular discomfort from the modified formulation.