High Sensitivity C-Reactive Protein As A Pote...

High Sensitivity C-Reactive Protein As A Potential Diagnostic Indicator Of Gestational Diabetes Mellitus In Pregnant Women

Author Name : Jain James, Jidhu G, Deepa Revi

ABSTRACT

Gestational diabetes is one of the most common medical conditions during pregnancy and its early detection is necessary to prevent prenatal and maternal complications. There is a link between raised high sensitivity C Reactive Protein (hs-CRP) and development of gestational diabetes. So the early detection of raised hs-CRP in blood may avoid serious maternal and neonatal hazards. The goal of this study was to detect and compare the prevalence of raised hs-CRP in normal pregnancy and in pregnancy with gestational diabetes mellitus (GDM) via a case-control retrospective study. Oral glucose tolerance test was performed on 100 pregnant women at 24-28 weeks of gestation to confirm diabetes mellitus. Out of the 100 pregnancy, 50 tested positive for diabetes and they were taken as the test (or case) group with GDM, the remaining 50 normal pregnancy was the control group. Both the case and control groups were investigated for the level of hs-CRP. The prevalence of hs-CRP in controls was 18%, whereas in cases it was 84%, with a p-value of less than 0.05 which is significant in this study. Thus the study showed that there exists a positive correlation between hs-CRP and GDM in pregnant women. An increase in the level of hs-CRP in pregnant women can be considered as a potential predictive indicator of developing GDM during later stages of pregnancy.

Key words- High sensitivity C reactive protein, gestational diabetes,  pregnancy