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Method Development and Validation of Nimesulide and Racemethionine in Combined Tablet Dosage form by UVAbsorbance Ratio Method
Author Name : Kalyani S. Nadgauda, D.P. Kardile, R.V. Shete, V.C. Bhagat
ABSTRACT A novel, simple, accurate, precise and reproducible UV-Spectrophotometric method is being build up for the simultaneous estimation of Nimesulide and Racemethionine in tablet dosage form for first time. The stock solutions were prepared in methanol and water. The λmax for Nimesulide and Racemethionine were 228 nm and 226 nm respectively with 215 nm Iso- Absorptive point. The both Nimesulide and Racemethionine complied Beer’s law in concentration range of 50-372ppm and 100-750ppm respectively. The Results of analysis of absorbance ratio method were analyzed and validated for various parameters in accordance with ICH guidelines for accuracy, precision, linearity, robustness, LOD and LOQ. The intended method is highly sensitive, precise and accurate, therefore can be used for intended purpose.