Nanotechnology in Drug Formulation & Developm...

Nanotechnology in Drug Formulation & Development a Critical Analysis

Author Name : Prof. (Dr.) Mohd Wasiullah, Prof. (Dr.) Piyush Yadav, Sujeet Kumar Patel, Shivendra Dubey

ABSTRACT Traditional drugs are facing bottlenecks of lower solubility, absorption, and especially the inefficient organs or cells targeting during the precision medicine era. It is urgently needed to discover and establish new methods or strategies to modify old drugs or create new ones against the above defects. Nanosuspension is an approach to deliver water insoluble and poorly bioavailable drugs by reducing size to submicron range. Thereby its dissolution rate is increased and hence the bioavailability, where drug dissolution rate is the limiting factor. Nanoemulsions are O/W or W/O emulsion, having droplet size from 20-200 nm that are transparent and do not have the tendency to coalesce. Nanoemulsions show great aesthetic appeal and skin feel and find their application in transdermal delivery of drugs, topical application for systemic drug delivery, oral delivery of proteins and delivering drugs through parenteral and intranasal routes. Nano micelles are self-assembling nano sized With the support of nanotechnology, the solubility, absorption and targeting of traditional drugs were greatly improved by modifying and fabricating with various types of nanoparticles to some extent, though many shortages remain. Application of biopharmaceutical concepts to formulation development has revolutionized strategy for dosage form design. Nanotechnology has become an essential element of pharmaceutical sciences and finds multiple applications in drug delivery systems in enhancing therapeutic performance of drugs. Many of the current “nano” drug delivery systems are pedigree of conventional dosage forms like nanosuspensions, nanoemulsions, and nanomicelles.