PLGA hybrid Nanoparticles: A promising system...

PLGA hybrid Nanoparticles: A promising system for drug delivery

Author Name : Preeti Sangwan

INTRODUCTION PLGA is biodegradable polyester used for the preparation of NPs for various molecular targets. It is synthesized by random ring-opening co-polymerization of copolymerization of glycolic acid and lactic acid in the presence of tin (II) 2- ethylhexanoate, tin (II) alkoxides or aluminum isopropoxide (1). It is one of the most widely used biocompatible and biodegradable polymers and has been approved by FDA for developing therapeutic device, due to its minimal systemic toxicity. PLGA can be hydrolyzed in the body and yield biodegradable lactic acid and glycolic acid and these hydrolysis products get metabolized in TCA cycle. There is very minimal systemic toxicity associated by using PLGA for drug delivery or biomaterial applications as the body very effectively deals with these two monomers. To develop a successful nanoparticulate system, drug release and polymer biodegradation are two important consideration factors that are mainly governed by the physicochemical properties of the polymer.