“Preparation and Characterization of Co-Cry...

“Preparation and Characterization of Co-Crystals: A Review”

Author Name : S. R. Burande, P. V. Gandhi, R. D. Chakole, M. S. Charde, K. B. Burade

ABSTRACT

According to the FDA co-crystals is defined as “Solids that are crystalline materials composed of two or more molecules in the same crystal lattice”. A subset of cocrystals are pharmaceutical cocrystals. A pharmaceutical co-crystal is a single crystalline solid that contains two neutral molecules, one of which is an API and the other a co-crystal former.In the field of pharmaceutical science and engineering, pharmaceutical cocrystals have rapidly progressed from relative obscurity to a well-studied class of crystal types.There are so many drugs which have low solubility therefore the bioavailability of such drugs is also less. To improve the solubility of such drugs, co-crystal is a novel approach. Cocrystals have the distinct advantage of maintaining the pharmacological properties of the Active Pharmaceutical Ingredient (API) while also attempting to enhance the coformers' physicochemical properties.This review covers the various techniques of co-crystal formation such as grinding, solvent evaporation, anti-solvent addition, slurring, etc. Further the prepared co-crystals can be characterized by Differential Scanning Calorimetry (DSC), X-ray Diffraction study (XRD), Fourier Transform Infra-red spectroscopy (FTIR), Scanning Electron Microscopy (SEM), etc. The properties of drug like melting point, mechanical strength, solubility, stability, etc. which are improved by co-crystals has also been described in this review.

Index Terms: Co-crystal, Co-former, Crystallization, Solubility.