Statistical Design, Formulation, and Evaluati...

Statistical Design, Formulation, and Evaluation of Empagliflozin-Loaded Ethosomes as Transdermal Drug Delivery Carriers

Author Name : P. Tejababu, M. V. Jhansipriya, Dr. Naidu Narapusetty, Sk. Meharaj

ABSTRACT Preventing type 2diabetes a metabolic condition requires adjusting one's diet exercising regularly, and keeping one's weight in check. People with type 2 DM want individualized care plans that improve their quality of life. We developed a new transdermal vesicular delivery method for Empagliflozin ethosomes in the current investigation. Box Behnken a design using-response surface method was used to improve the cold-prepared Empagliflozin ethosomes. Empagliflozin ethosomes were tuned and characterized for EE, VS, ZP, PDI, and shape using scanning electron microscopy Empagliflozin was successfully incorporated into ethosomes, as shown by DSC and FT-IR tests demonstrating its amorphous condition in ethosomes. In vitro transdermal absorption and skin retention studies showed that ethosome-encapsulated Empagliflozin exhibited significantly higher cumulative penetration (Qn) and in vitro permeation compared to that of 25% pure drug solution, indicating not only improved transdermal absorption but also increased storage in the skin. Ethanol-phospholipid-cholesterol ethosomes exhibited excellent features, including good skin permeability and adequate stability, and hence represent a promising approach for Empagliflozin.