Study of Inflammatory Markers in Chronic Kidn...

Study of Inflammatory Markers in Chronic Kidney Disease

Author Name : Ms. Farha Khan

ABSTRACT

Objectives:- The aim of the present study was to estimate the levels of CRP & ESR activity in patient of CKD. This study also correlate the levels of CRP & ESR with Serum Urea, Uric acid & Creatinine respectively.
Methods:- This study includes 60 patients within the age of 18 – 60 years. Total 5ml of blood was collected from each subject. 3ml was collected in a plain vial and remaining was collected in EDTA vial. Serum CRP (mg/dl) concentration was measured by Latex agglutination test & ESR (mm/hour) was measured by Wintrobe’s method. Serum Creatinine (mg/dl), Urea (mg/dl) & Uric acid (mg/dl) concentration was measured by Modified Jaffe’s method, Urease & Uricase method respectively.
Results:- In the present study, serum CRP & ESR was increased in CKD patients. The mean serum CRP levels of CKD patients & controls were 33.55 ± 22.8 & 2.07 ± 6121 respectively ( p< 0.001 ), highly significant result was observed. Mean level of serum ESR ( 40.25 ± 14.93 ) of cases shows statistical significant differences as compared with the mean of serum ESR of controls ( 13.50 ± 3.421 ).
Conclusion:- CRP & ESR are the markers used to evaluate kidney disease, however , each of these has its own limitation. The use of these inflammatory biomarkers may better assess overall patients risk & be able to stage patients more appropriately.