Sulbactam and Durlobactam: An Analytical Pers...

Sulbactam and Durlobactam: An Analytical Perspective on Β-Lactamase Inhibition and Resistance Management

Author Name : Krishnaphanisri Ponnekanti, Addanki Anusha, B. Raj Kamal, Maddikunta Srilekha

ABSTRACT Sulbactam irreversibly inhibits the hydrolytic activity of β-lactamases. This compound is commercially available in combination with either ampicillin or cefoperazone. One of the particular advantages of using sulbactam containing combinations is that sulbactam itself has inherent activity against some Acinetobacter baumannii. Sulbactam is a first generation β-lactamase inhibitor with activity limited to a subset of class A enzymes that also has direct-acting antibacterial activity against Acinetobacter spp. Durlobactam is a new member of the diazabicyclooctane class of β-lactamase inhibitors with broad spectrum activity against Ambler class A, C, and D serine β-lactamases .