The influence of local administration of calc...

The influence of local administration of calcitonin and alendronate on bone formation marker (osteocalcin) in critical size defect: An experimental study in sheep

Author Name : Wafaa k. Abid, Mohammed K. Hassouni

ABSTRACT
Aims: This study was undertaken to investigate the influence of local administration of Calcitonin and Alendronate on bone formation marker (Osteocalcin).
Materials and Methods: Eleven male sheep were divided into 3 groups: control (n=3), Calcitonin treated (n=4), and Alendronate treated animals (n=4), and followed up at 2, 4, 8, and 12weeks. Bone defects 5mm in diameter and 5mm in depth were created with a standard trephine bur in tibia of the sheep. The tested materials were placed in the defect. Serum Osteocalcin was measured in four period of times (pre-operative time, 24 h, 72 h, and 7 days post-operatively) using ELISA.
Results: Alendronate and Calcitonin revealed a tendency to increase in Osteocalcin level but not reach to statistically significance when comparing to control group.
Conclusions: Locally applied Alendronate and Calcitonin may be considered among therapeutic option to improve bone formation process in different bone remodeling cases. Further studies are required to elucidate the effect of local delivery of Alendronate and Calcitonin on bone formation markers.
Keywords: Bone formation, Bisphosphonates, Calcitonin, Osteocalcin.