A Review of Analytical Methods for Ranolazine

A Review of Analytical Methods for Ranolazine

Author Name : P. Pravalika , G. Jephthah , Jayanti Mukherjee

ABSTRACT Ranolazine Hydrochloride (RAN) is a piperazine derivative used as anti-ischemic drug for the treatment of angina. Ranolazine is used for the treatment of cardiac ischemia and it effects sodium dependent calcium channel during myocardial ischemia. As a consequence, ranolazine prevents reverse mode sodium-calcium exchange and thus diastolic accumulation of calcium possibly resulting in improved diastolic tone and improved coronary blood flow. This review article represents the various analytical methods which has been reported for estimation of Ranolazine in synthetic mixture. The spectrophotometric techniques like fluorescent assay and area under curve spectroscopy; Chromatographic methods like HPLC, HPTLC and RP HPLC, GC, LC-MS, LC-MS/MS were reported.