A Review on Analytical Methods For Estimation...

A Review on Analytical Methods For Estimation of Vortioxetine In Bulk And Pharmaceutical Dosage Form

Author Name : Aishwarya Anil Nirmal, S. S. Siddheshwar, R.D. Ghogare

ABSTRACT

Vortioxetine is a novel antidepressant used for the treatment of major depressive disorder (MDD). Depression is a prevalent mental health illness thought to be caused by a serotonin and norepinephrine imbalance, as well as a variety of environmental, cognitive, and physical factors. Major depressive disorder (MDD) is a severe and disabling mental illness that is frequently accompanied by cognitive impairment. Attention, memory, executive function, and processing speed may all be affected by depression-related dysfunction. In vulnerable patients, acute serotonin (5HT) depletion impairs memory and mood. Tricyclic antidepressants, monoamine oxidase inhibitors, and selective serotonin and norepinephrine uptake inhibitors have traditionally been used to treat depression. Vortioxetine belongs to the serotonin modulator and stimulator family of antidepressants. The Fever method of analytical research has been reported for the estimation of the above drug. which are HPLC, RP-HPLC, UPLC-MS, HPLC-UV, and HPTLC. The objective behind this review work is to study the analyatical work done on Vortioxetine.

KEYWORDS:Vortioxetine, HPLC, RP-HPLC, UPLC-MS, HPLC-UV, HPTLC, LC-MS.