A Review on Phytosomes: Approach for Drug Del...

A Review on Phytosomes: Approach for Drug Delivery of Herbal Phytochemicals

Author Name : Kajal R. Pawar , Assistant Prof. Manish P. Surung

DOI: https://doi.org/10.56025/IJARESM.2023.11102346

ABSTRACT The poor oral bioavailability of polyphenolic compounds can be enhanced through the incorporation of them into phospholipid-based self-assembled delivery system, i.e. popularly known as phytosome. “Phyto” means plants and “some” resembles a covering around/or a structure. Phytosome is generally prepared by reacting one or two moles of polyphenolic phytoconstituents and phospholipid. It may be either in the ratio of 1:1 and 1:2. By using phytosomes, one can also achieve enhanced rate and extent of the passage of lipophilic herbal constituents across lipid membrane that explains its character as a carrier, as well as acid labile herbal drugs, could also be protected in the gastrointestinal tract. There are number of products available in the market that contains phytosomal drug delivery system such as Ginkgo biloba, Silybum marianum, and Camellia sinensis. The present review describes an updated overview of the preparation of phytosomes, advancement in phytosomes technology, various herbal drugs for which phytosomes have been used as a carrier, its commercial availability and applications.