An Overview of Pyrazolopyrimidine Hybrids wit...

An Overview of Pyrazolopyrimidine Hybrids with Their Biological Activities

Author Name : Dolphy Anto, Menna Chandran, Ashly George, Jismy Francis, Vishnu P V, Silvipriya K S, K Krishna Kumar

ABSTRACT

A pyrazole's fused N-heterocyclic systems are known as pyrazolopyrimidines. Which have many important applications, such as medicinal, pharmaceuticals, pesticides, dyes, and pigments and they are regarded as a key structural motif. Pyrazolopyrimidines are fused heterocyclic ring systems that are structurally equivalent to adenine, a nucleotide essential for all aspects of cellular life. In recent decades, their synthetic routes have increased significantly. The current review is an examination of various pyrazolopyrimidines with their recent applications. Synthesis of fused pyrimidine compounds was first reported in mid-1950. Since then, thousands of derivatives have been synthesized by applying numerous synthetic strategies and analyzed for their pharmacological properties. It was initially created and tested as adenosine nucleoside analogues for antiviral and anticancer treatments. The pyrazolopyrimidine nucleus used as a pharmacophore in the development of pharmaceuticals, promotes a variety of biological actions.

Keywords: Anti-cancer, Purine, Pyrimidine, Pyrazoline.