Breast Cancer Subtypes Based on ER/PR and Her...

Breast Cancer Subtypes Based on ER/PR and Her2 Expression Exploration and Its Comparison with Different Ethnic Population

Author Name : Khriesivonuo Nakhro, Diptendu Chatterjee, Arup Ratan Bandyopadhyay

DOI: https://doi.org/10.56025/IJARESM.2023.11523119

ABSTRACT

Objectives: The diversity of breast cancer at the molecular level is etiologically and clinically significant as different subtypes demonstrate different survival rates. In addition, the unequal distribution of molecular subtypes by race/ ethnicity may account for racial/ethnic disparities in breast cancer outcomes. The study attempt to explore molecular subtypes and compare with other ethnic population. Methods: A total of 61 cases of invasive breast cancer were interviewed from Christian Institute of Health Sciences & Research (CIHSR), Eden Medical Centre and Putuonuo Hospital, Nagaland. Data were abstracted and analyzed from the hospital medical records. Results: Triple Negative Breast Cancer (TNBC) and Luminal A subtypes constitute 32.8% and 39.3% respectively. The study demonstrates comparatively good percentage of Luminal A, as compared to North East region, but found lower as compared to other states in India and very low when compared with international studies, USA.  Conclusion: The present study showed Luminal A as the preponderant subtype followed by TNBC. Observing international studies, the in­cidence of luminal A has remained preponderant subtype, followed by luminal B, HER2, and lastly TNBC, on the contrary Indian studies demonstrate the incidence of Luminal subtypes followed by TNBC, which is known for its aggressiveness and poor survival.

Keywords: Subtype, Breast Cancer, Nagaland, Prognosis, Survival