“Comparative Study and Characterization of ...

“Comparative Study and Characterization of Green Chemistry Synthesized Acetaminophen with Chemically Synthesized Acetaminophen”

Author Name : Mrs. Sheela Thorat, Ms. Sanika R. Powar, Ms. Utkarsha R. Powar, Ms. Aishwarya M. Pujari, Mr. Amit P. Raskar

ABSTRACT This study focuses on the eco-friendly synthesis of acetaminophen utilizing sustainable green chemistry methodologies. The research involved the meticulous utilization of P-amidophenol, glacial acetic acid, and hydrogen peroxide to produce the pharmaceutical compound. The synthesized acetaminophen underwent comprehensive characterization through various analytical techniques, including IR and UV spectral analysis, ensuring the assessment of its purity and structural integrity. Moreover, the project emphasized the comparison of the green chemistry synthesized acetaminophen with chemically synthesized acetaminophen, evaluating their respective spectral signatures. This comprehensive analysis contributes valuable insights into the sustainable manufacturing practices and the comparative quality assessment of green-synthesized pharmaceutical products. Acetaminophen was synthesized from phenol in three steps. In this synthetic route the solvent from step two was kept to help maximize atom economy. The first step was an Electrophilic aromatic substitution on phenol with nitric acid to create p-nitrophenol. Next, P-¬nitrophenol was used to synthesize p-aminophenol through hydrogenation using a tincatalyst. Lastly, acetaminophen was synthesized by the acylation of the aminophenol. This new method including the green step minimized chemical waste.