Eco Friendly Synthesis of Methoxy Substituted...

Eco Friendly Synthesis of Methoxy Substituted Derivatives of Coumarin Using Phosphotugstic acid as an effective Catalyst and Study their anti-inflammatory Properties

Author Name : Anna R. Anthony

ABSTACT

Coumarins and their derivatives are the structural unit of several natural products¹,and are biologically active and widely occur in nature². Their applications range from pharmaceuticals³, optical brighteners⁴, and laser dyes⁵. Also, coumarins and functionalized coumarins have shown activity as antimicrobials and chemotherapeutics⁶. Some Coumarinderivates have been widely used as an important chemical in perfume, cosmetic as well as pharmaceutical industrial preparation. Phosphotungsticacid (H₃PW₁₂O₄₀) a commercially available environmentally benign catalyst non-toxic widely used for the synthesis of the substituted coumarin. Owing to the numerous advantages associated with cheap and non-hazardous catalyst, and also realizing g the importance of coumarin herein we would like to focus the eco –friendly method for his synthesis of derivatives of coumarin using cheaper and commercially available acid catalyst Phosphotungsticacid(H₃PW₁₂O₄₀)and also by the Knoevenagel condensation under microwave irradiation.This methodology offers significant improvements for the synthesis of derivativeofcoumarin with regard to yield of products, simplicity in operation and green aspects by avoiding toxic conventional catalysts and solvents. The coupling of microwave heating with solid phase catalysts in solvent-free conditions  catalysis chemical processes with special attributes such as s enhanced reaction rate,  Therefore owing the importance of Phosphotungsticacid  (H₃PW₁₂O₄₀) a facile catalyst used for the green synthesis of derivatives of coumarin .The methoxy Derivatives of coumarinswreecharacterized by IR and NMR spectroscopy.This  derivative of the coumarin was studied its  anti-inflammatory activity. Anti-inflammatory activity of the newly synthesised Coumarin has been evaluated by calculating the percentage protection or percentage inhibition which was calculated by following equation.% protection= [O.D of control – O.D of test/ O.D of control x 100Where O.D stands for optical density.

Keywords: Phosphotungsticacid(H₃PW₁₂O₄₀), microwave irradiation,anti inflammatory