Formulation And Development Of Piroctone Olamineniosomal Topical Drug Delivery By Using Quality By Design Approach

Author Name : Patoliya Chiragkumar Manubhai, Professor Bhavna Joshi, Dr. Chainesh Shah, Dr. Umesh M. Upadhyay

ABSTRACT

The present study was focused on investigating niosomal gels loaded with Piroctone Olamine, for prolonged residence time and improved bioavailability for treatment of dandruff. Preformulation study of drug was carried out to check the identification of purity of drug. Piroctone Olamine niosomes were prepared using various concentration of nonionic surfactants (span 60), in the presence of cholesterol in different molar ratios by ether injection method. Prepared Niosomes evaluated for Particle size, PDI, Entrapment Efficiency and %CDR. The selected formulations were incorporated into various concentration of carbopol based gels.  Optimized formulation was evaluated for their physical parameters Viscosity, pH, spreadability, Permeability co-efficient, in-vitro drug release, Skin irritancy test and also stability  Study of formulation were done. Primary identification of drug showed that drug was pure. Screening of different variables was identified that Concentration of Span 60, Concentration of Cholesterol and stirring speed were the most influential factors affecting the Yield, Entrapment Efficiency and %CDR. Formulation composed of span 60 and cholesterol (1:1) gave the highest entrapment (80.67± 1.89%) and slower release results after 8 hours among other formulations. The in-vitro drug permeation studies showed that there was a prolonged release of drug from niosomal gels as compared to niosomes itself. Considering the in-vitro drug release, niosomal gel formulation 1 was the best among the studied formulations. The release data were fitted to an empirical equation, which indicated that the release follows Higuchi model diffusion mechanism. The stability study revealed that incorporation of niosomes in gel increased their stability than the niosome itself. These results suggest that the niosomal gels containing Piroctone Olamine are promising ocular carriers for dandruff treatment.

Keyword: Niosome, Topical drug delivery, Novel drug delivery System, Piroctone olamine