Formulation and Development of Quetiapine Fum...

Formulation and Development of Quetiapine Fumarate Nano Suspension Using Design of Experiment

Author Name : Jugvi Patel, Mansi Patel, Dr. Chainesh Shah, Dr. Jigar Vyas, Dr. U M Upadhyay

Main objectives to develop Quetiapine Fumarate Nanosuspension are to enhance solubility and dissolution rate of poorly soluble Drug (Quetiapine Fumarate), substantially leading to its bioavailability enhancement & Improvement of aqueous and saturation solubility in turn rapid release of Drug which leads to enhancing therapeutic efficacy. A 32 full factorial design was applied to examine the combined effect of two formulation variables, each at 3 levels and the possible 9 combinations of Quetiapine Fumarate Nanosuspension were prepared. Quetiapine Fumarate Nanosuspension was prepared by quasi solvent evaporation method with help of different polymer and concentration. There was changes polymer ratio, volume of organic solvent and stirring speed. Quetiapine Fumarate nanosuspension gives immediate release and showing highest dissolution rate within 10 minutes comparison with marketed formulations. Quetiapine Fumarate Nanosuspension compacts may enhance aqueous solubility and dissolution rate in compare to other solubility enhancement technique hence, this research work may be useful to formulate Quetiapine Fumarate Nanosuspension which may give rapid onset of action by rapid absorption, maximize efficacy, dose frequency & hence increase patient Compliance.

Keywords: Quetiapine Fumarate, Nan suspension, solubility enhancement, dissolution enhancement.