Formulation and Evaluation In Situ Nasal Gel ...

Formulation and Evaluation In Situ Nasal Gel Of Lamotrigine With β-Cyclodextrin Complex

Author Name : Mrs. Mangalbai B. Chavan, Mrs. Dr. Shubhangi C. Daswadkar

ABSTRACT

Nasal pathway achieved faster and greater level of drug absorption due to more surface area. The preventing first passes metabolism and readily accessibility. LMT is widely useful for the treatment of epilepsy. It is useful for various types of partial-onset and generalised-onset seizures.

The main objective of present investigation is to formulate and evaluate the in-situ nasal gel of LMT with beta-cyclodextrin complex by making beta cyclodextrin inclusion complex improves the solubility f LMT because the drug which are used in the present investigation is anti-epileptic drug belongs to BCS class II drug having low solubility and high permeability through the beta cyclodextrin inclusion complex increase the solubility of drug by making as an in-situ nasal gel formulation. To overcome the first pass effect, increase residence time of drug, improve patient compliance, improving bioavailability, reduce dosing frequency, and reduce mucocilliary clearance etc. formulation optimised by using central composite design as a response surface method. Through this method total 9 formulations were obtained. Then evaluation of optimised batch was done, it includes clarity, pH, viscosity, drug release, spreadability etc. The drug release of optimised (F1) formulation up to 81.73% and has Spreadability with 5.98gm cm/sec. as compared to marketed formulation it enhance the bioavailability and as per the need of time to go for the further pre-clinical study to get better exposure for current research.

Keywords: Lamotrigine, beta-cyclodextrine, in-situ gel, nasal, inclusion complex