Formulation and Evaluation of Controlled Rele...

Formulation and Evaluation of Controlled Release Naproxen Microsphere Loaded Gel for the Treatment of Inflammation

Author Name : Mr. Gaurav Anil Patil, Mr. Nilesh R. Bhosle, Dr. Rajashree S. Chavan, Mr. Gaurav V. Tekade, Mr. Prasad S. Wagh, Mr. Aniket V. Chandankhede

ABSTRACT Topical controlled release drug delivery system is getting greater attention due to its therapeutic advantages. Naproxen is a non-steroidal anti-inflammatory drug with potent analgesic and anti-arthritic properties. In the present study, a suitable particulate system of Naproxen has been developed by Solvent evaporation method for controlled release that would result in prolong drug release, reduced frequency of administration and lesser side effects. Different ratios and percentages of hydroxypropyl methyl cellulose and ethyl cellulose were used to formulate the microspheres. The effect of various formulation variables on evaluation parameters such as size, entrapment efficiency, drug content and in vitro release of naproxen were studied. Gel was formulated of Formulation No. 5 which was optimised batch.