Formulation and In-Vitro Evaluation of Itopri...

Formulation and In-Vitro Evaluation of Itopride HCl Loaded Gastro-Retentive Floating Microsponges

Author Name : Shri Prakash Sharma, Abadhesh Kumar Niranjan2

ABSTRACT The gastro-retentive floating microsponge drug delivery System, can mitigate variations in medication plasma levels and result in decreased adverse effects, increased dosing frequency, and improved patient adherence. The observed absorbance maximum of Itopride HCl in a 0.1 N HCl solution is at a wavelength of 258 nm. The calibration curves exhibit exceptional linearity of the data, as evidenced by correlation coefficient values over 0.99. The current work utilized the quasi-emulsion solvent diffusion method to construct eight gastro-retentive Floating Microsponge compositions of Itopride HCl. In order to standardize their impact on the drug-release pattern, varying quantities of polymers such as Eudragit S-100, polyvinyl alcohol, ethyl cellulose, Dichloromethane, and tween 80 were employed. Approximately 80% of the formulations adhered to the desired drug release pattern within a time frame of 12 hours. The assessment of floating microsponges involved evaluating many factors such as angle of repose, bulk density, tapped density, compressibility index, Hausner's ratio, particle size determination, floating time, % entrapment efficiency, percentage buoyancy, and in-vitro drug release. Surface morphology and shape of manufactured floating microsponges were examined using Scanning electron microscopy. The optimized formulation exhibited drug release 85.36% within 12 hours. The ability of all formulations to float was evaluated by measuring the in vitro buoyancy study of floating microsponges. All of the developed formulations exhibited buoyancy for a minimum duration of 8 to 12 hours.