Formulation & Evaluation of Dapagliflozin Pro...

Formulation & Evaluation of Dapagliflozin Propanediol Monohydrate NLCs.

Author Name : Sohail Khan Sayeed Khan, Dr. S. C. Atram

ABSTRACT

NLCs have provoked the incessant impulsion for the development of safe and valuable drug delivery systems owing to their exceptional physicochemical and then biocompatible characteristics. Throughout the earlier period, a lot of studies recounting NLCs based formulations have been noticeably increased. They are binary system which contains both solid and liquid lipids aiming to produce less ordered lipidic core. Their constituents particularly influence the physicochemical properties and effectiveness of the final product. NLCs can be fabricated by different techniques which are classified according to consumed energy. More utilization NLCs is essential due to overcome barriers surrounded by the technological procedure of lipid-based nanocarriers’ formulation and increased information of the core mechanisms of their transport via various routes of administration. They can be used in different applications and by different routes such as oral, cutaneous, ocular and pulmonary. The reported records evidently demonstrate the promise of NLCs for innovate therapeutic applications in the future. In this study, DPM-NLCs were fabricated and characterized by particle size, % entrapment efficiency, % drug release and TEM study.

Key words: NLCs, dapagliflozin propanediol monohydrate, lipid-based nanocarriers.