Formulation & Evaluation of Solid Self Emulsi...

Formulation & Evaluation of Solid Self Emulsifying Drug Delivery System of Ritonavir

Author Name : Mr. Aniket Rajendra Bhagwat, Mr. K N Tarkase, Mrs. N S Pawar

ABSTRACT

The oral delivery of hydrophobic drugs presents a major challenge because of the low aqueous solubility of such compounds. Solid Self emulsifying drug delivery systems (S-SEDDS), which are isotropic mixtures of oils, surfactants, solvents and co-solvents/surfactants, are of crucial importance for the design of formulations that will improve the oral absorption of hydrophobic drug compounds. S-SEDDS are orally administered in soft or hard gelatin capsules and form fine relatively stable oil−in−water (o/w) emulsions upon aqueous dilution owing to the gentle agitation of the gastrointestinal fluids.

Ritonavir being one of the lipophilic drug is formulated to self-emulsifying drug delivery system. Formulated liquid formulation is checked for various emulsion parameters. Solidified SEDDS using adsorption carrier method was put for evaluation of powdered characteristics, stability & compatibility testing. The fact that almost 40% of the new drug compounds are hydrophobic in nature implies that studies with S-SEDDS will continue, and more drug compounds formulated as S-SEDDS will reach the pharmaceutical market in the future.

Conclusion: The obtained results conclude the potentiality of S-SEDDS of RTV to increase the bioavailability & efficiency while decreased metabolic load on human body.

Keywords: Ritonavir, Solid-SEDDS