Formulation of Nanoparticle to Enhance the So...

Formulation of Nanoparticle to Enhance the Solubility or Dissolution Rate of Acyclovir

Author Name : Omkar T. Ghumare, Dhananjay Landge, Sachin Anbhule, Jaydeep Pawar, Sunil Nirmal

ABSTRACT

PEG 6000& HPMC were used to produce nanoparticles of poorly soluble antiviral drugs using a rapid precipitation process. The structure-property relationships of PEG& HPMC polymers were studied for their solubility enhancement of poorly soluble drugs. Particles were purified by dialysis, and dried powders were recovered after freeze-drying. The particle diameters were 150–200 nm. The target drug loading in the particles was 25 wt%, and the drug loading efficiencies were 80–96%. The effects of the formulation process and nanoparticle properties on drug solubility were investigated. All nanoparticles afforded increased solubility and faster release compared to pure drugs. Drug release was a function of the relative hydrophobicity (or solubility parameters) of the polymers.

Keywords: Solid dispersions, Acyclovir,Nanoparticles, Precipitation, Solubility.